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Side effects that can occur with long-term Ativan use and abuse include: drowsiness, visual disturbance, memory loss, depression, nausea or vomiting, a heachache, hallucinations, violent mood changes, aggressive behavior ,suicidal tendencies.
One of the most dangerous side effects of prolonged Ativan use is seizures. While Ativan may be prescribed to help alleviate seizures, the way that it affects the brain can actually cause seizures if it is used excessively.
Pre-medication with lorazepam may lower the dose of the fentanyl derivative required for an introductory general anesthetic, and shorten the time to loss of consciousness with induction doses. Reduces the effectiveness of levodopa in patients with Parkinsonism.
May increase the toxicity of zidovudine.
Ethanol, etc. drugs that depress the central nervous system (phenothiazine, narcotic analgesics, barbiturates), MAO inhibitors, etc. antidepressants increase neurotropic activity and increase the inhibitory effect on the central nervous system.
Simultaneous reception of cimetidine does not affect kinetics.
The drugs that block tubular secretion can disrupt the glucuronide binding of Lorazepam, which leads to an increase in its effect and, possibly, excessive sedation.
Inhibitors of microsomal oxidation prolong T1 / 2, increase the risk of toxic effects. Inducers of microsomal liver enzymes reduce efficacy.
The narcotic analgesics intensify euphoria, leading to an increase in psychological dependence. Hypotensive drugs can increase the severity of blood pressure lowering. Against the background of simultaneous administration of clozapine, an increase in respiratory depression is possible.