igetropin plays a crucial role in muscle regeneration. IGF-1 stimulates both proliferation and differentiation of stem cells in an autocrine-paracrine manner, although it induces differentiation to a much greater degree. IGF-1,when injected locally, increases satellite cell activity, muscle DNA, muscle protein content, muscle weight and muscle cross sectional area. The importance of IGF-1 lies in the fact that all of its apparent functions act to inducemuscle growth with or without overload although it really shines as a growth promoter when combined with physical loading of the muscle.
IGF-1 also acts as an endocrine growth factor having an anabolic effect on distant tissues once released into the bloodstream by the liver. IGF-1 possesses the insulin-like property of inhibiting degradation, but in addition can stimulate protein synthesis. The insulin-like effects are probably due to the similarity of the signaling pathways between insulin and IGF-1 following ligand binding at the receptors.
The ability of IGF-I to stimulate protein synthesis resembles the action of GH, which was shown in separate studies on volunteers to stimulate protein synthesis without affecting protein degradation. Although it is often believed that the effects of GH are mediated through IGF-1, this cannot be the case entirely. First, the effects of the two hormones are different, in that GH does not change protein degradation. Second, the effect of GH is observed with little or no change in systemic IGF-1concentrations. Age related muscle loss has been prevented with GH injections, however it is believed that this is accomplished through IGF-1.
IGETROPIN (INSULINE GROWTH FACTOR) BY HYGENE: RESULTS, DOSAGES AND SIDE EFFECTS
Igetropin is an injectable drug manufactured by Hygene, China and containing IGF-I (Insulin-like Growth Factor) and IGF-II belonging to the family of insulin-like growth factors that are structurally homologous to proinsulin. These compounds are present in many tissues and cell types and may have autocrine, paracrine and endocrine functions. In medicine it is also useful in treatment of kidney disease, osteoporosis (condition resulting in reduced bone mineral density, also known as brittle bones), atherosclerosis (inflammation of the walls of the arteries) and myotonic muscular dystrophy. Igetropin come in kits containing 25 vials x 100 mcg/vial.
The main effect of Igetropin is regulation of glycogen metabolism. It also has anabolic features. This drug induces transportation of glycogen and amino acids within muscular and other tissues. This preparation can also increase protein anabolism. It is a growth factor and it is one of the most potent in human body. IGF causes muscle cell hyperplasia, which is an actual splitting and forming of new muscle cells. Another advantage that Igetropin has over other hormones is that it has much more of an affinity to attach to muscle cells instead of bone and organ cells.
Igetropin is most effective when administered subcutaneous and injected once or twice daily. The best period for injections is either in the morning or immediately after weight training. The most effective length for a cycle of Igetropin is 50 days on and 20-40 days off. The average dosage is quite controversial in using this medication. The most used dosages range between 20 mcg per day and up to 120 mcg per day. IGF is only available by the milligram, one mg will give you a 50 day cycle at 20 mcg per day, 2 mg will give you a 50 day cycle at 40 mcg per day, and so on. Hypoglycemic effects of this compound can be reduced by intake of oral contraceptives, corticosteroids, thyroid hormone preparations, diazoxid, tricyclic antidepressants and some other medicines.